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Upcoming ISCHEMIA Presentations

  • Optimal medical therapy in the International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA)-Chronic Kidney Disease (CKD): A comparison of patients on and not on dialysis at baseline. (To be presented by Dr. Roy Matthew at ASN October 2020)

  • Clinical And Quality Of Life Outcomes With Chronic Total Occlusion In ISCHEMIA: ISCHEMIA CTO Substudy. (To be presented by Dr. Sripal Bangalore at AHA November 2020) (LBCT)

  • Causes Of Cardiovascular And Non-cardiovascular Mortality In The ISCHEMIA Trial (To be presented by Dr. Mandeep Sidhu at AHA November 2020)

Recent ISCHEMIA Presentations

  • Outcomes with Intermediate Left Main Disease on Coronary CT Angiography in the ISCHEMIA trial. (Presented by S. Bangalore at SCAI May 2020) Link
  • Coronary Anatomy, Ischemia and Angina: Associations at Baseline in the ISCHEMIA trial. (Presented by H. Reynolds at ACC March 2020) Link
  • Variation in Myocardial Infarction Rates By Type And Definition In the ISCHEMIA Trial. (Presented by B. Chaitman at ACC March 2020) Link
  • Predictions of Left Main Disease Using Clinical and Stress Test Parameters. (Presented by R. Senior at ACC March 2020) Link
  • Relationships Of Ischemia Severity And Coronary Artery Disease Extent With Clinical Outcomes In The Ischemia Trial. (Presented by D. Maron at ACC March 2020) Link
  • Clinical And Quality Of Life Outcomes With Invasive Versus Conservative Strategy In Patients With Stable Ischemic Heart Disease Across The Spectrum Of Baseline Kidney Function: Insights From The ISCHEMIA And ISCHEMIA-CKD Trials. (Presented by S. Bangalore at ACC March 2020) Link
  • Natural History Of Symptoms And Stress Echo Findings In Patients With Moderate Or Severe Ischemia And No Obstructive CAD (INOCA): The NHLBI-funded CIAO Ancillary Study To The ISCHEMIA Trial. (Presented by H. Reynolds at ACC March 2020) Link

Recent ISCHEMIA Publications

  • Lopes RD, Alexander KP, Stevens SR, Reynolds HR, Stone GW, Pina IL, Rockhold FW, Elghamaz A, Lopez-Sendon JL, Farsky PS, Chernyavskiy AM, Diaz A, Phaneuf D,  DeBelder MA, Ma Y, Guzman LA, Khouri M, Sionis A, Hausenloy DJ, Doerr R, Selvanayagam JK, Maggioni AP, Hochman JS, Maron DJ.  Initial Invasive versus Conservative Management for Stable Ischemic Heart Disease with a History of Heart Failure or Left Ventricular Dysfunction: Insights from the ISCHEMIA Trial. AHA Journals. Aug 29 2020 Link
  • Bangalore S, Maron D, Stone GW, Hochman J. Routine Revascularization versus Initial Medical Therapy for Stable Ischemic Heart Disease: A Systematic Review and Meta-Analysis of Randomized Trials. AHA Journals. Jun 26 2020 Link
  • Spertus JA, Jones PG, Maron DJ, Mark DB, O'Brien SM, Fleg JL, Reynolds HR, Stone GW, Sidhu MS, Chaitman BR, Chertow GM, Hochman JS, Bangalore S. Health Status after Invasive or Conservative Care in Coronary and Advanced Kidney Disease. The New England Journal of Medicine. April 23 2020 Link
  • Bangalore S, Maron DJ, O'Brien SM, Fleg JL, Kretov EI, Briguori C, Kaul U, Reynolds HR, Mazurek T, Sidhu MS, Berger JS, Mathew RO, Bockeria O, Broderick S, Pracon S, Herzog CA, Huang Z, Stone GW, Boden WE, Newman JD, Ali ZA, Mark DB, Spertus JA, Alexander KP, Chaitman BR, Chertow GM, Hockman JS. Management of Coronary Disease in Patients with Advanced Kidney Disease. The New England Journal of Medicine. April 23 2020 Link
  • Spertus JA, Jones PG, Maron DJ, O'Brien SM, Reynolds HR, Rosenberg Y, Stone GW, Harrell FE, Boden WE, Weintraub WS, Baloch K, Mavromatis K, Diaz A, Gosselin G, Newman JD, Mavromichalis S, Alexander KP, Cohen DJ, Bangalore S, Hochman, JS, Mark DB. Health-Status Outcomes with Invasive or Conservative Care in Coronary Disease. The New England Journal of Medicine. April 9 2020 Link
  • Maron DJ, Hochman JS, Reynolds HR, Bangalore S, O'Brien SM, Boden WE, Chaitman BR, Senior R, López-Sendón J, Alexander KP, Lopes RD, Shaw LJ, Berger JS, Newman JD, Sidhu MS, Goodman SG, Ruzyllo W, Gosselin G, Maggioni AP, White HD, Bhargava B, Min JK, Mancini GBJ, Berman DS, Picard MH, Kwong RY, Ali ZA, Mark DB, Spertus JA, Krishnan MN, Elghamaz A, Moorthy N, Hueb WA, Demkow M, Mavromatis K, Bockeria O, Peteiro J, Miller TD, Szwed H, Doerr R, Keltai M, Selvanayagam JB, Steg PG, Held C, Kohsaka S, Mavromichalis S, Kirby R, Jeffries NO, Harrell FE, Rockhold FW, Broderick S, Ferguson Jr. TB, Williams DO, Harrington RA, Stone GW, Rosenberg Y. Initial Invasive or Conservative Strategy for Stable Coronary Disease. The New England Journal of Medicine. April 9 2020 Link
  • Reynolds HR, Shaw LJ, Min JK, Spertus JA, Chaitman BR, Berman DS, Picard MH, Kwong RY, Bairey-Merz CN, Cyr DD, Lopes RD, Lopez-Sendon JL, Held C, Szwed H, Senior R, Gosselin G, Nair RG, Elghamaz A, Bockeria O, Chen J, Chernyavskiy AM, Bhargava B, Newman JD, Hinic SB, Jaroch J, Hoye A, Berger J, Boden WE, O'Brien SM, Maron DJ, Hochman JS. Association of Sex With Severity of Coronary Artery Disease, Ischemia, and Symptom Burden in Patients With Moderate or Severe Ischemia Secondary Analysis of the ISCHEMIA Randomized Clinical Trial. JAMA Cardiology. March 30, 2020 Link

The ISCHEMIA and ISCHEMIA-CKD Study Results are available! Please click HERE to see the study results!

What is the ISCHEMIA Study? 

  • An NHLBI-funded international comparative effectiveness study to determine the best way to manage stable ischemic heart disease.
  • Patients with moderate or severe ischemia, with or without stress imaging, may be eligible for participation.

If you are a physician and would like more information, please visit the For Physicians section.

If you are a patient and would like to learn more about the ISCHEMIA study, please visit the For Patients section. 

Why is the ISCHEMIA Study Important?

Ischemic heart disease (IHD) is the leading cause of death and disability worldwide and affects 17,600,000 Americans, resulting in about 450,000 deaths in the United States annually. Globally, 7.2 million deaths are caused by IHD each year.

Medical therapy (medication and lifestyle changes) should always be used to treat IHD. Many doctors routinely use an invasive approach in addition to medical therapy to treat IHD. The trial showed that heart procedures added to taking medicines and making lifestyle changes did not reduce the overall rate of heart attack or death compared with medicines and lifestyle changes alone. However, for people with chest pain symptoms, heart procedures improved symptoms better than medicines and lifestyle changes alone. The more chest pain to begin with, the more symptoms improved after getting a stent or bypass surgery. 

Total Number of Participants Randomized to the ISCHEMIA Trial

There are 5,179 participants (pts) randomized worldwide in the ISCHEMIA study. Click here to see the randomizations by country.