What is the ISCHEMIA Study? 

  • An NHLBI-funded international comparative effectiveness study to determine the best way to manage stable ischemic heart disease.
  • Patients with moderate or severe ischemia, with or without stress imaging, were eligible for participation.

Why is the ISCHEMIA Study Important?

Ischemic heart disease (IHD) is the leading cause of death and disability worldwide and affects 17,600,000 Americans, resulting in about 450,000 deaths in the United States annually. Globally, 7.2 million deaths are caused by IHD each year.

Medical therapy (medication and lifestyle changes) should always be used to treat IHD. Many doctors routinely use an invasive approach in addition to medical therapy to treat IHD. The trial showed that heart procedures added to taking medicines and making lifestyle changes did not reduce the overall rate of heart attack or death compared with medicines and lifestyle changes alone. However, for people with chest pain symptoms, heart procedures improved symptoms better than medicines and lifestyle changes alone. The more chest pain to begin with, the more symptoms improved after getting a stent or bypass surgery. 

Total Number of Participants Randomized to the ISCHEMIA Trial

There are 5,179 participants (pts) randomized worldwide in the ISCHEMIA study. Click here to see the randomizations by country.

The ISCHEMIA and ISCHEMIA-CKD Study Results can be found HERE!


Upcoming ISCHEMIA Presentations

No upcoming presentations at this time. Stay tuned for updates!

Recent ISCHEMIA Presentations

  • Clinical And Quality Of Life Outcomes With Chronic Total Occlusion In ISCHEMIA: ISCHEMIA CTO Substudy. (Presented by Dr. Sripal Bangalore at AHA November 2020) (LBCT) Link
  • Causes Of Cardiovascular And Non-cardiovascular Mortality In The ISCHEMIA Trial (Presented by Dr. Mandeep Sidhu at AHA November 2020) Link
  • Optimal medical therapy in the International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA)-Chronic Kidney Disease (CKD): A comparison of patients on and not on dialysis at baseline. (Presented by Dr. Roy Matthew at ASN October 2020) Link
  • Outcomes with Intermediate Left Main Disease on Coronary CT Angiography in the ISCHEMIA trial. (Presented by S. Bangalore at SCAI May 2020) Link
  • Coronary Anatomy, Ischemia and Angina: Associations at Baseline in the ISCHEMIA trial. (Presented by H. Reynolds at ACC March 2020) Link

For more Presentations, please CLICK HERE.

Recent ISCHEMIA Publications

  • Lopes RD, Alexander KP, Stevens SR, Reynolds HR, Stone GW, Pina IL, Rockhold FW, Elghamaz A, Lopez-Sendon JL, Farsky PS, Chernyavskiy AM, Diaz A, Phaneuf D,  DeBelder MA, Ma Y, Guzman LA, Khouri M, Sionis A, Hausenloy DJ, Doerr R, Selvanayagam JK, Maggioni AP, Hochman JS, Maron DJ.  Initial Invasive versus Conservative Management for Stable Ischemic Heart Disease with a History of Heart Failure or Left Ventricular Dysfunction: Insights from the ISCHEMIA Trial. AHA Journals. Aug 29 2020 Link
  • Bangalore S, Maron D, Stone GW, Hochman J. Routine Revascularization versus Initial Medical Therapy for Stable Ischemic Heart Disease: A Systematic Review and Meta-Analysis of Randomized Trials. AHA Journals. Jun 26 2020 Link
  • Spertus JA, Jones PG, Maron DJ, Mark DB, O'Brien SM, Fleg JL, Reynolds HR, Stone GW, Sidhu MS, Chaitman BR, Chertow GM, Hochman JS, Bangalore S. Health Status after Invasive or Conservative Care in Coronary and Advanced Kidney Disease. The New England Journal of Medicine. April 23 2020 Link
  • Bangalore S, Maron DJ, O'Brien SM, Fleg JL, Kretov EI, Briguori C, Kaul U, Reynolds HR, Mazurek T, Sidhu MS, Berger JS, Mathew RO, Bockeria O, Broderick S, Pracon S, Herzog CA, Huang Z, Stone GW, Boden WE, Newman JD, Ali ZA, Mark DB, Spertus JA, Alexander KP, Chaitman BR, Chertow GM, Hockman JS. Management of Coronary Disease in Patients with Advanced Kidney Disease. The New England Journal of Medicine. April 23 2020 Link
  • Maron DJ, Hochman JS, Reynolds HR, Bangalore S, O'Brien SM, Boden WE, Chaitman BR, Senior R, López-Sendón J, Alexander KP, Lopes RD, Shaw LJ, Berger JS, Newman JD, Sidhu MS, Goodman SG, Ruzyllo W, Gosselin G, Maggioni AP, White HD, Bhargava B, Min JK, Mancini GBJ, Berman DS, Picard MH, Kwong RY, Ali ZA, Mark DB, Spertus JA, Krishnan MN, Elghamaz A, Moorthy N, Hueb WA, Demkow M, Mavromatis K, Bockeria O, Peteiro J, Miller TD, Szwed H, Doerr R, Keltai M, Selvanayagam JB, Steg PG, Held C, Kohsaka S, Mavromichalis S, Kirby R, Jeffries NO, Harrell FE, Rockhold FW, Broderick S, Ferguson Jr. TB, Williams DO, Harrington RA, Stone GW, Rosenberg Y. Initial Invasive or Conservative Strategy for Stable Coronary Disease. The New England Journal of Medicine. April 9 2020 Link

For more Publications, please CLICK HERE.