Total ISCHEMIA Randomizations





The ISCHEMIA Design Paper has been Published!

The ISCHEMIA Design Paper was published in the American Heart Journal July 2018 edition (Vol. 201) on pages 124-135.  A PDF copy of the paper can be found here.


What is the ISCHEMIA Study? 

  • An international comparative effectiveness study
  • The purpose of ISCHEMIA is to determine the best way to manage stable ischemic heart disease.
  • Patients with moderate or severe ischemia, with or without stress imaging, may be eligible for participation.

If you are a physician and would like more information, please visit the For Physicians section.

If you are a patient and would like to learn more about the ISCHEMIA study, please e-mail ischemia@nyulangone.org

Why is the ISCHEMIA Study Important?

Ischemic heart disease (IHD) is the leading cause of death and disability worldwide and affects 17,600,000 Americans, resulting in about 450,000 deaths in the United States annually. Globally, 7.2 million deaths are caused by IHD each year.

Medical therapy (medication and lifestyle changes) should always be used to treat IHD. Many doctors routinely use an invasive approach in addition to medical therapy to treat IHD; however, it is not known if this approach is better than medical therapy alone as the initial treatment of patients with stable ischemic heart disease (SIHD), moderate to severe ischemia. ISCHEMIA is designed to find the answer.


Total Number of Participants Randomized to the ISCHEMIA Trial

There are 5,179 participants (pts) randomized worldwide in the ISCHEMIA study. Click here to see the randomizations by country.

Congratulations To Our Top Sites!

Site name Region Study Team Total Rands

Government Medical College


PI: Dr. Sajeev & Dr. Nair SC: Anand, Raj, Ravindran, & Vijayan Sunitha

208 pts

Northwick Park Hospital- Royal Brompton Hospital, London


PI: Senior Co-PI: Elghamaz SC: Kinsey, Kavalakkat, Howard, Bucaj, & Encarnado

202 pts

Sri Jayadeva Institute of Cardiovascular Sciences and Research, Banglore-Karnataka India PI: Dr. Manjunath & Dr. Moorthy SC: Nataraj, Kumbar, & Nayak

149 pts

Atlanta V.A. Medical Center


PI: Dr. Mavromatis SC: Lee, Patel, & Doan

139 pts

Heart Instituto do Coracao - University of Sao Paulo


PI: Dr. Hueb SC: Takiuti

127 pts

Coronary and Structural Heart Diseases Department, Institute of Cardiology, Warsaw


PI: Prof. Demkow SC: Chojnacka, Frelek, & Pracon 127 pts
Hospital Universitario La Paz Spain PI: Dr. Lopez-Sendon SC: Valbuena, Castro, La Paz Mediavilla, Albaladejo & Fernandez-Figares  118 pts
Bakulev Scientific Center for Cardiovascular Surgery Russia PI: Dr. Bockeria SC: O. Bockeria, Aripova & Kudzoeva  113 pts

Complejo Hospitalario Universitario de A Coruna


PI: Dr. Peteiro SC: Blanco & Garcia Gonzalez

 112 pts

Guangdong General Hospital

China PI: Dr. Chen SC: Dong, He, Xia, Yang, & Zhong  102 pts